Nakhjavani Manouchehr, Morteza Afsaneh, Esteghamati Alireza, Khalilzadeh Omid, Zandieh Ali, Safari Reza
Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Lipids. 2011 Apr;46(4):349-56. doi: 10.1007/s11745-010-3513-1. Epub 2010 Dec 14.
Women with diabetes are faced with a higher risk of dyslipidemia and cardiovascular disorders than men with diabetes. We aimed to study the role of gender and menopausal status in serum Lp(a) levels in patients with type 2 diabetes. We quantified serum Lp(a) levels in a group of 477 patients with type 2 diabetes (men, premenopausal and postmenopausal women with diabetes), as well as in 105 controls. We stratified the patients into two groups of low Lp(a) levels (Lp(a) <35 mg/dl) and elevated Lp(a) levels (Lp(a) >35 mg/dl). Patients with diabetes had higher serum Lp(a) levels than the controls. Serum Lp(a) levels was significantly higher in women with diabetes than men with diabetes. Lp(a) levels did not differ between male and females in the control group. Premenopausal and postmenopausal women with diabetes did not differ significantly in serum Lp(a) levels. The odds ratio of having a serum Lp(a) level higher than 35 was 5.85 in premenopausal women with diabetes, 5.08 in postmenopausal women with diabetes, 2.41 in men with diabetes and 1.9 in the women in the control group compared to the men in the control group, after adjustment for age and BMI. This observational study clearly indicated that serum Lp(a) levels were significantly higher in women and men with diabetes. The increase in women was independent of menopause. The level of serum Lp(a) had no correlation with lipid parameters in men or women.
与患有糖尿病的男性相比，患有糖尿病的女性面临着更高的血脂异常和心血管疾病风险。我们旨在研究性别和绝经状态在2型糖尿病患者血清Lp(a)水平中的作用。我们对一组477例2型糖尿病患者（男性、绝经前和绝经后糖尿病女性）以及105名对照者的血清Lp(a)水平进行了定量分析。我们将患者分为两组，即低Lp(a)水平组（Lp(a)<35mg/dl）和高Lp(a)水平组（Lp(a)>35mg/dl）。糖尿病患者的血清Lp(a)水平高于对照组。糖尿病女性的血清Lp(a)水平显著高于糖尿病男性。对照组中男性和女性的Lp(a)水平无差异。绝经前和绝经后糖尿病女性的血清Lp(a)水平无显著差异。在调整年龄和BMI后，与对照组男性相比，绝经前糖尿病女性血清Lp(a)水平高于35的比值比为5.85，绝经后糖尿病女性为5.08，糖尿病男性为2.41，对照组女性为1.9。这项观察性研究清楚地表明，糖尿病男性和女性的血清Lp(a)水平显著更高。女性的升高与绝经无关。血清Lp(a)水平与男性或女性的血脂参数均无相关性。
