Cui S, Li G
Tumor Hospital of Guang Zhou.
Zhonghua Zhong Liu Za Zhi. 1995 Jul;17(4):304-6.
A method of receptor binding assay (RBA) was adopted to measure the distribution of androgen receptor (AR) in liver cancer and tissue in its vicinity in 63 patients with primary liver cancer undergone laparotomy and in non-tumor liver tissue in 7 cases with gastric carcinoma. The results showed (1) AR was demonstrated in the liver cancer tissue and surrounding non-tumorous tissue, and the non-tumor liver tissue. The content of AR in the nucleus was significantly higher than that in the cytoplasm. (2) There was no difference in the amount of AR between the tumor tissue and tissue surrounding it. The expression of AR in the liver cancer tissue or the surrounding tissue was more marked than that in the non-tumor tissue. (3) Expression of AR in the tumor tissue seemed to correlate with more frequent tumor recurrence one year after radical resection.
采用受体结合分析法（RBA）检测63例接受剖腹手术的原发性肝癌患者肝癌组织及其附近组织以及7例胃癌患者非肿瘤性肝组织中雄激素受体（AR）的分布。结果显示：（1）肝癌组织、周围非肿瘤组织及非肿瘤性肝组织中均检测到AR。细胞核中AR的含量显著高于细胞质。（2）肿瘤组织与其周围组织中AR的含量无差异。肝癌组织或其周围组织中AR的表达比非肿瘤组织更明显。（3）肿瘤组织中AR的表达似乎与根治性切除术后1年更频繁的肿瘤复发相关。
