Liang L, Lu M, Huang J
Department of Hepatobiliary Surgery, First Affiliated Hospital of Sun Yat-sen University of Medical Sciences, Guangzhou.
Zhonghua Zhong Liu Za Zhi. 1996 May;18(3):214-7.
To investigate the reasons why primary liver cancer (hepatocellular carcinoma, HCC) is prevalent in male, androgen receptors (AR) in cytoplasm and nucleus were quantitatively detected in tumor tissue and tumor-adjacent tissue of 23 patients with HCC and liver tissue of normal livers by means of receptor radio-ligand binding assay. The concentrations of AR in cytoplasm and nucleus were as follows: 0.20-5.30, 1.91-6.50 fmol/mg protein in normal liver tissue; 5.12-27.62, 10.73-47.18 fmol/mg protein in tumor tissue; and 3.18-14.98, 5.15-36.32 fmol/mg protein in tumor-surrounding tissue. The mean concentrations of AR in cytoplasm or nucleus decreased in the order of tumor tissue, tumor-surrounding tissue and normal liver tissue, and the differences among them were statistically significant. The concentration of AR in tumor tissue and tumor-adjacent tissue had no direct or indirect association with sex, age, abuse of alcohol, HBsAg, HBcAb, AFP, pathological type of tumor, differentiation degree of tumor cells and the underlying liver disease. The result suggests that the prevalence of HCC in male over in female in China may be somehow related to the expression of AR in tumor cells.
为探讨原发性肝癌（肝细胞癌，HCC）男性高发的原因，采用受体放射配体结合分析法，对23例HCC患者的肿瘤组织、癌旁组织及正常肝脏组织中的细胞质和细胞核雄激素受体（AR）进行定量检测。正常肝脏组织细胞质和细胞核中AR的浓度分别为：0.20 - 5.30、1.91 - 6.50 fmol/mg蛋白；肿瘤组织中为：5.12 - 27.62、10.73 - 47.18 fmol/mg蛋白；癌旁组织中为：3.18 - 14.98、5.15 - 36.32 fmol/mg蛋白。细胞质或细胞核中AR的平均浓度依次为肿瘤组织、癌旁组织、正常肝脏组织，且三者之间差异具有统计学意义。肿瘤组织和癌旁组织中AR的浓度与性别、年龄、饮酒史、HBsAg、HBcAb、AFP、肿瘤病理类型、肿瘤细胞分化程度及基础肝病均无直接或间接关联。结果提示，中国男性HCC发病率高于女性可能与肿瘤细胞中AR的表达有关。
