Li J, Li L, Kang S
Department of Oncology, Nanfang Hospital, First Military Medical University, Guangzhou.
Zhonghua Zhong Liu Za Zhi. 1995 Jul;17(4):314-5.
Brain metastasis is of frequent occurrence in patients with cancer of the lung. To ascertain if brain metastasis is preventable, 34 lung cancer patients without brain metastasis were treated with 4 cycles of VM-26 plus CCNU at 4-week intervals. As a control for comparison, an equal number of lung cancer patients free of brain metastasis were treated with chemotherapy protocol which did not include VM-26 and CCNU. The patients were monitored by clinical symptoms, signs and CT or MRI scan and were followed up for 4-12 months. The results indicate that none of the VM-26 plus CCNU-treated patients developed brain metastasis while brain metastasis occurred in 7 (20.5%) of 34 control patients. The difference was statistically significant (P < 0.05).
脑转移在肺癌患者中很常见。为了确定脑转移是否可以预防，34例无脑转移的肺癌患者接受了4个周期的VM - 26加环己亚硝脲治疗，间隔4周。作为对照比较，同等数量的无脑转移肺癌患者接受不包括VM - 26和环己亚硝脲的化疗方案治疗。通过临床症状、体征以及CT或MRI扫描对患者进行监测，并随访4至12个月。结果表明，接受VM - 26加环己亚硝脲治疗的患者均未发生脑转移，而34例对照患者中有7例（20.5%）发生了脑转移。差异具有统计学意义（P < 0.05）。
