Wamae C N, Lammie P J, Muttunga J N
Department of Parasitology, Tulane University, New Orleans, Louisiana, USA.
East Afr Med J. 1995 Aug;72(8):492-4.
Forty-five serum specimens collected from persons living in a filaria-endemic community in Maili Nane, Coastal Kenya were analyzed by ELISA for levels of isotype specific antifilarial antibody and by Og4C3 ELISA for circulating parasite antigen. Mean levels of IgG1, IgG2, and IgG3 were lower in microfilaraemic persons than in amicrofilaraemic individuals. In contrast, mean levels of antifilarial IgG4 were significantly higher in microfilaraemic persons (p = 0.0374). Serum samples from all microfilaremic persons were positive for circulating antigen as were 15% of samples from amicrofilaremic and asymptomatic persons. The Og4C3 antigen assay may have value as a technique for identifying and targeting communities for control efforts.
对从肯尼亚沿海地区马利纳内一个丝虫病流行社区的居民采集的45份血清样本进行了分析，通过酶联免疫吸附测定法（ELISA）检测同种型特异性抗丝虫抗体水平，并通过Og4C3 ELISA检测循环寄生虫抗原。微丝蚴血症患者的IgG1、IgG2和IgG3平均水平低于无微丝蚴血症个体。相比之下，微丝蚴血症患者的抗丝虫IgG4平均水平显著更高（p = 0.0374）。所有微丝蚴血症患者的血清样本循环抗原呈阳性，无微丝蚴血症和无症状患者的样本中有15%呈阳性。Og4C3抗原检测作为一种识别和确定控制工作目标社区的技术可能具有价值。
Zotero 插件