Puech A J, Corruble E
Départment de Pharmacologie, Hôpital de la Salpêtrière, Paris.
Encephale. 1995 Mar;21 Spec No 2:17-21.
Concerning depressive disorders, biological factors remain relatively unknown. However, they might first be risk factors for depressive disorders and secondly could decrease the response to antidepressants. We studied hypothyroidism, diabetes and hypothalamic-pituitary-adrenal axis disorders. In terms of neurotransmitters, beta-adrenergic dysfunction may be involved in hypothyroidism and diabetes whereas a serotonergic dysfunction may be involved in hypothalamic-pituitary-adrenal axis disorders.
关于抑郁症，生物学因素仍相对不为人知。然而，它们可能首先是抑郁症的危险因素，其次可能会降低对抗抑郁药的反应。我们研究了甲状腺功能减退症、糖尿病和下丘脑-垂体-肾上腺轴紊乱。就神经递质而言，β-肾上腺素能功能障碍可能与甲状腺功能减退症和糖尿病有关，而血清素能功能障碍可能与下丘脑-垂体-肾上腺轴紊乱有关。
