Llorca P M, Reine G, Wolf M A
Service de psychiatrie d'adultes, Hbopital Sainte-Marguerite, Marseille.
Can J Psychiatry. 1993 Dec;38(10):649-56. doi: 10.1177/070674379303801005.
Modifications in noradrenergic and serotonergic systems are involved in the central mechanism of action of antidepressants. Most antidepressants (electroconvulsive therapy included) induce a desensitization of the beta-noradrenergic receptor, as shown by a decrease in noradrenaline-stimulated cAMP production. Down-regulation of the beta receptor is often associated with desensitization, as well as modifications in the activity of the serotonergic system, among which alternations in 5-HT2 receptors are frequent. Finally, complex interactions between noradrenergic and serotonergic receptors may also contribute to the pharmacological effect of long term antidepressive treatment.
去甲肾上腺素能和血清素能系统的改变参与了抗抑郁药的中枢作用机制。大多数抗抑郁药（包括电休克疗法）会诱导β-去甲肾上腺素能受体脱敏，这表现为去甲肾上腺素刺激的环磷酸腺苷（cAMP）生成减少。β受体的下调通常与脱敏以及血清素能系统活性的改变有关，其中5-HT2受体的变化很常见。最后，去甲肾上腺素能和血清素能受体之间的复杂相互作用也可能有助于长期抗抑郁治疗的药理作用。
