Hardy P
Service de Psychiatrie d'adultes, CHU de Bicêtre, Le Kremlin Bicêtre.
Encephale. 1995 Mar;21 Spec No 2:39-42.
It is now recognised that the treatment of depressive episodes comprises three distinct phases: the phase of acute treatment, which should lead to symptomatic remission; the phase of continuation, which aims to obtain cure by preventing relapses; and the phase of maintenance or prophylactic treatment, the object of which is to prevent recurrence, that is to say the occurrence of a new depressive episode independent of the earlier one. The application of such a therapeutic protocol to mood alterations raises a number of questions. In the first place, it should be emphasised that the fluctuating character and low intensity of the mood-changing symptoms, as well as the normally progressive action of antidepressants over time may make it very difficult to date the onset of remission. For this reason, the phases of acute treatment and of consolidation may not be discernible for a certain period of time. Furthermore, the chronicity of time-course being one of the principal characteristics of dysthymias, the only effective long-term therapeutic strategy may be to pursue continuation treatment instead of maintenance treatment, on the grounds that every new symptomatic manifestation should be regarded as a relapse rather than a recurrence. The duration of continuation treatment is poorly defined. If credence is lent to the rule which states that a depressive state should be treated for as long as the prior history has lasted, consolidation treatment of dysthymias should be continued for several years--two at least, more frequently more, and sometimes indefinitely.(ABSTRACT TRUNCATED AT 250 WORDS)
现在人们认识到,抑郁发作的治疗包括三个不同阶段:急性治疗阶段,应导致症状缓解;巩固阶段,旨在通过预防复发实现治愈;维持或预防性治疗阶段,其目的是防止复发,即发生与之前发作无关的新的抑郁发作。将这样一种治疗方案应用于情绪改变会引发一些问题。首先,应该强调的是,情绪改变症状的波动性和低强度,以及抗抑郁药随时间的通常渐进作用,可能使得很难确定缓解开始的时间。因此,在一段时间内可能无法区分急性治疗阶段和巩固阶段。此外,病程的慢性是恶劣心境的主要特征之一,唯一有效的长期治疗策略可能是进行巩固治疗而非维持治疗,因为每一个新的症状表现都应被视为复发而非再次发作。巩固治疗的持续时间定义不明确。如果相信“抑郁状态应治疗至既往病史持续的时长”这一规则,恶劣心境的巩固治疗应持续数年——至少两年,更常见的是更长时间,有时甚至是无限期。(摘要截选至250词)