Wacker J, Piel P, Lewicka S, Haack D, Vecsei P, Bastert G
Department of Obstetrics and Gynecology, University of Heidelberg, Germany.
Endocr Res. 1995 Feb-May;21(1-2):197-202. doi: 10.3109/07435809509030435.
In the present study the aldosterone-18-glucuronide and tetrahydroaldosterone values in 24 hour urine collections of healthy nonpregnant women, women with normal pregnancies and women with pregnancy induced hypertension (PIH) were compared. In pregnancy an elevated excretion of both aldosterone metabolites was found. The Q-ratio (aldosterone-18-glucuronide/tetrahydro-aldosterone+aldosterone-18-glu cur onide) was also increased compared to healthy nonpregnant women. The elevated Q-ratios point out to increased formation of aldosterone-18-glucuronide. This predominantly renal metabolite may reflect greater availability of aldosterone molecules for interaction with mineralocorticoid receptor in the kidney.
在本研究中，比较了健康未孕女性、正常妊娠女性和妊娠高血压综合征（PIH）女性24小时尿液收集物中醛固酮-18-葡萄糖醛酸苷和四氢醛固酮的值。在妊娠期间，发现两种醛固酮代谢产物的排泄量均升高。与健康未孕女性相比，Q比值（醛固酮-18-葡萄糖醛酸苷/四氢醛固酮+醛固酮-18-葡萄糖醛酸苷）也升高。升高的Q比值表明醛固酮-18-葡萄糖醛酸苷的形成增加。这种主要在肾脏产生的代谢产物可能反映了更多的醛固酮分子可用于与肾脏中的盐皮质激素受体相互作用。
