Fujimoto S, Kitsukawa U, Itoh K
Ann Surg. 1979 Jan;189(1):34-8. doi: 10.1097/00000658-197901000-00007.
Carcinoembryonic antigen (CEA) levels in the feces and serum were evaluated in 22 colorectal cancer patients and 20 healthy volunteers; in CEA levels gastric juice and serum were also evaluated in 28 gastric cancer patients and 14 peptic ulcer patients. Fecal CEA was found in all of 22 colorectal cancer patients as well as in the 20 healthy volunteers. Elevated fecal CEA levels were observed in the colorectal cancer patients, as compared to the healthy volunteers. The feces of 15 of the 22 colorectal cancer patients contained CEA at concentrations higher than the mean value plus twice the standard deviation of the healthy volunteers. The fecal CEA levels did not correlate directly either with Dukes' stage or serum CEA levels. CEA in gastric juice was elevated significantly in 26 of gastric cancer patients, with the exception of two patients with early gastric cancer. On the other hand, serum CEA was elevated in only nine of the 28 gastric cancer patients. These results point out the distinct value of assaying CEA in the feces or gastric juice as an aid in the diagnosis of colorectal or gastric cancer.
对22例结直肠癌患者和20名健康志愿者的粪便和血清癌胚抗原(CEA)水平进行了评估;对28例胃癌患者和14例消化性溃疡患者的胃液和血清CEA水平也进行了评估。在22例结直肠癌患者以及20名健康志愿者中均检测到粪便CEA。与健康志愿者相比,结直肠癌患者的粪便CEA水平升高。22例结直肠癌患者中有15例粪便中CEA浓度高于健康志愿者平均值加两倍标准差。粪便CEA水平与Dukes分期或血清CEA水平均无直接相关性。除2例早期胃癌患者外,26例胃癌患者的胃液CEA显著升高。另一方面,28例胃癌患者中只有9例血清CEA升高。这些结果表明,检测粪便或胃液中的CEA对结直肠癌或胃癌的诊断具有独特价值。