胃液中癌胚抗原样物质的研究。

Studies on the CEA-like substance in gastric juice.

作者信息

Kawaharada M, Fukuya S, Suzuki T, Sudo M, Akahonai Y, Yachi A, Wada T

出版信息

Gastroenterol Jpn. 1978;13(1):8-12. doi: 10.1007/BF02774148.

Abstract

Concentration and heterogeneity of CEA-like substance in gastric juice were studied using radioimmunoassay. Statistically significant increase of CEA-like substance in gastric juice was found in advanced atrophic gastritis (P less than 0.01), early gastric cancer (P less than 0.05) and advanced gastric cancer (P less than 0.01) as compared with normal subjects. In cases with atrophic gastritis with a high degree of intestinal metaplasia, the concentrations above 300 microgram/dl were noticed. The results indicate that increased concentrations of CEA-like substance in gastric secretions may strongly suggest the presence of a marked intestinal metaplasia and/or cancerous changes of gastric mucosae, including the early cancer. The distribution of CEA activity in gel filtration fractions of gastric juice was compared using kits of two different radioimmunoassay systems. The patterns of CEA activities were different between the two different kits used, but the main peaks were located in the fractions with the molecular weight of 20x10(4) daltons corresponding to that of serum CEA. It is considered, however, that the CEA-like substance in gastric juice specimens may be more or less heterogenous when any of the methods is used.

摘要

采用放射免疫分析法研究了胃液中癌胚抗原（CEA）样物质的浓度及异质性。与正常受试者相比，发现晚期萎缩性胃炎（P<0.01）、早期胃癌（P<0.05）和晚期胃癌（P<0.01）患者胃液中CEA样物质有统计学意义的增加。在高度肠化生的萎缩性胃炎病例中，发现浓度高于300微克/分升。结果表明，胃液中CEA样物质浓度升高可能强烈提示胃黏膜存在明显的肠化生和/或癌变，包括早期癌症。使用两种不同放射免疫分析系统的试剂盒比较了胃液凝胶过滤组分中CEA活性的分布。所用的两种不同试剂盒的CEA活性模式不同，但主峰位于分子量为20×10⁴道尔顿的组分中，与血清CEA相对应。然而，认为无论使用哪种方法，胃液标本中的CEA样物质可能或多或少存在异质性。