Nishiyama T
Department of Anaesthesiology, JR Tokyo General Hospital, Japan.
Eur J Anaesthesiol. 1995 Jul;12(4):369-74.
To study post-operative analgesia with epidural midazolam, 30 patients who had undergone upper abdominal surgery were divided into two equal groups. When patients complained of pain, they were given either 6 microliters 0.25% bupivacaine (control group) or 6 microliters 0.25% bupivacaine + 0.05 mg kg-1 midazolam (midazolam group) epidurally at a single level between T7 and T12. Blood pressure and heart rate were similar in the two groups. Sedation was significantly greater in the midazolam group 10 min after administration. The area of analgesia was significantly larger in the midazolam group 10 and 30 min after administration and involved the entire spinal area and the head and face 10 min after administration in six patients. Amnesia was observed in 14 patients in the midazolam group but in only one in the control group. Epidural midazolam together with bupivacaine adds central analgesic, sedative, and amnesic effects to spinal analgesia and is useful for managing post-operative pain.
为研究硬膜外给予咪达唑仑的术后镇痛效果，将30例接受上腹部手术的患者分为两组，每组15例。当患者主诉疼痛时，于T7至T12之间的单一平面硬膜外给予6微升0.25%布比卡因（对照组）或6微升0.25%布比卡因+0.05毫克/千克咪达唑仑（咪达唑仑组）。两组患者的血压和心率相似。给药后10分钟，咪达唑仑组的镇静作用明显更强。给药后10分钟和30分钟，咪达唑仑组的镇痛面积明显更大，给药后10分钟，6例患者的镇痛区域累及整个脊髓节段以及头面部。咪达唑仑组有14例患者出现遗忘，而对照组仅有1例。硬膜外给予咪达唑仑联合布比卡因可增强脊髓镇痛的中枢镇痛、镇静和遗忘作用，有助于术后疼痛的管理。
