Parkkila S, Ahonen A, Torniainen P, Heikkilä J, Salmela P
Division of Nuclear Medicine, University of Oulu, Finland.
Eur J Nucl Med. 1995 Sep;22(9):1064-8. doi: 10.1007/BF00808419.
Four patients with medullary thyroid carcinoma (MTC) were examined using anti-carcinoembryonic antigen (CEA) scintigraphy. Two patients had positive and two normal scintigraphic findings, although all the patients had elevated blood test markers (calcitonin or CEA). One patient with clinical suspicion of MTC metastases had only a faintly positive anti-CEA image, although single-photon emission tomographic scanning was used to increase the sensitivity and resolution of the method. Therefore, digital image processing of the planar images was performed to obtain more detailed information. The analysis revealed distinct accumulation of the activity at the right side of the neck at 20 h post administration. The specificity of the antibody binding in the malignant cells was confirmed after surgery by immunohistochemical staining of the tumour specimens for CEA. Both conventional and confocal laser scanning microscopy revealed distinct positive staining, indicating that the results obtained from the anti-CEA scanning showed specific binding of the labelled antibody in the neoplastic tissue.
对4例甲状腺髓样癌（MTC）患者进行了抗癌胚抗原（CEA）闪烁扫描检查。尽管所有患者的血液检测指标（降钙素或CEA）均升高，但2例患者的闪烁扫描结果为阳性，2例正常。1例临床怀疑有MTC转移的患者，尽管使用了单光子发射断层扫描来提高该方法的灵敏度和分辨率，但抗CEA图像仅呈弱阳性。因此，对平面图像进行了数字图像处理以获得更详细的信息。分析显示，给药后20小时，颈部右侧有明显的放射性聚集。术后通过肿瘤标本的CEA免疫组织化学染色证实了抗体在恶性细胞中的特异性结合。传统显微镜和共聚焦激光扫描显微镜均显示出明显的阳性染色，表明抗CEA扫描获得的结果显示标记抗体在肿瘤组织中具有特异性结合。
