Erzurumlu K, Ozdemir M, Mihmanli M, Cevikbaş U
Department of General Surgery, OMU School of Medicine, Samsun, Turkey.
Eur Surg Res. 1995;27(5):340-5. doi: 10.1159/000129418.
Caustic sclerosing cholangitis occurs with the use of scolicidal solutions in liver hydatid disease draining into the biliary system. In this study, we investigated the effectiveness of benzimidazole solutions, their in vitro scolicidal effects and the histopathological changes in the hepatobiliary system due to their intraoperative use. It was found that 5 mg% mebendazole and 1 mg% albendazole have strong scolicidal effects. In an in vivo study, under general anesthesia, 5% mebendazole in group I, 1% albendazole in group II and normal saline in group III were injected into the biliary system of rabbits. Liver biochemical tests showed no significant changes. More elaborate ductal mucosal proliferation, ductal dilatation and periductal fibrosis were found in group I compared with group II in biopsies taken on the 60th day. The biopsies of group III were normal.
在肝包虫病中，当使用排入胆道系统的杀头节剂溶液时会发生腐蚀性硬化性胆管炎。在本研究中，我们研究了苯并咪唑溶液的有效性、它们的体外杀头节作用以及术中使用它们后肝胆系统的组织病理学变化。结果发现，5mg%的甲苯达唑和1mg%的阿苯达唑具有很强的杀头节作用。在一项体内研究中，在全身麻醉下，将第一组的5%甲苯达唑、第二组的1%阿苯达唑和第三组的生理盐水注入兔的胆道系统。肝脏生化检查未显示明显变化。在第60天采集的活检中，与第二组相比，第一组发现更明显的导管黏膜增生、导管扩张和导管周围纤维化。第三组的活检结果正常。
