Erzurumlu K, Hokelek M, Baris S, Sahin M, Birinci A, Amanvermez R, Tac K
Department of General Surgery, OMU School of Medicine, Samsun, Turkey.
Eur Surg Res. 1998;30(6):433-8. doi: 10.1159/000008610.
The use of scolocidal solutions in the hepatobiliary system may result in caustic sclerosing cholangitis. In this study, the effectivenes of a biological metabolite of albendazole, albendazole sulfoxide, on scolices and the hepatobiliary system was evaluated. In the in vitro study, it was found that 100 microg/ml albendazole sulfoxide solution had strong scolocidal effect in 15 min. In the in vivo study, two experimental groups, each consisting of 8 rabbits aged 3-4 months and weighing 2,500 +/- 250 g, 100 microg/ml albendazole sulfoxide and normal saline were given into the biliary tract. ALP, GGT, SGOT and SGPT values on days 7, 30 and 60 were not found to be significantly increased compared to preoperative values. Total bilirubin values were high in the working group 7 and 30 days postoperatively and on day 30 in the control group, returning back to normal levels on day 60 in both groups. Histopathological evaluation of the liver parenchyma and the biliary system on day 60 revealed no differences between the groups. Consequently, albendazole sulfoxide solution may be used intraoperatively for scolocidal purposes.
在肝胆系统中使用杀头节剂溶液可能会导致腐蚀性硬化性胆管炎。在本研究中，评估了阿苯达唑的一种生物代谢产物阿苯达唑亚砜对头节和肝胆系统的有效性。在体外研究中，发现100μg/ml阿苯达唑亚砜溶液在15分钟内具有很强的杀头节作用。在体内研究中，将两个实验组，每组由8只3 - 4个月大、体重2500±250g的兔子组成，分别向其胆道内注入100μg/ml阿苯达唑亚砜和生理盐水。与术前值相比，第7天、30天和60天时碱性磷酸酶（ALP）、γ-谷氨酰转肽酶（GGT）、谷草转氨酶（SGOT）和谷丙转氨酶（SGPT）的值未发现显著升高。术后第7天和30天，工作组的总胆红素值较高，对照组在第30天时总胆红素值较高，两组在第60天时均恢复到正常水平。术后第60天对肝实质和胆道系统进行组织病理学评估，结果显示两组之间无差异。因此，阿苯达唑亚砜溶液可在手术中用于杀头节目的。
