Xiao S H, Yang Y Q, Guo H F, Zhang C W, Jiao P Y, You J Q, Jiao W
Institute of Parasitic Diseases, Chinese Academy of Preventive Medicine, Shanghai.
Zhongguo Yao Li Xue Bao. 1990 Nov;11(6):546-9.
Mice infected with protoscoleces of Echinococcus granulosus for 8-9 months were treated ig with mebendazole (Meb) 50 mg.kg-1.d-1, albendazole (Alb) 300 mg.kg-1.d-1 or albendazole sulfoxide (AlbSO) 150 mg.kg-1.d-1 for 1-7 d. The glycogen contents of cyst wall in each drug groups were 1.0 +/- 0.6 - 1.8 +/- 0.9 mg/g, 1.1 +/- 0.9 - 1.8 +/- 0.8 mg/g and 0.8 +/- 0.5 - 1.5 +/- 0.9 mg/g, respectively, which were less than those 2.2 +/- 1.3 - 2.8 +/- 1.3 mg/g of corresponding control groups with respective glycogen reduction rates of 38-55%, 36-51% and 46-62%. After prolongation of treatment course to 10-14 d, the glycogen contents of cyst wall in Meb and AlbSO groups were further decreased, which resulted in glycogen reduction rates of 73% and 69%, respectively. No further decrease of glycogen contents in Alb groups was seen as the glycogen reduction rates sustained in 32%. Histochemical observation showed that the glycogen contents in germinal layer of the cysts decreased significantly or even disappeared during the treatment of Meb, Alb or AlbSO. The results suggested that the effects of Meb and AlbSO on mice infected with secondary cysts of E granulosus were superior to Alb as evaluated by glycogen reduction rate of cyst wall.
用细粒棘球绦虫原头蚴感染小鼠8 - 9个月后，分别以50 mg·kg⁻¹·d⁻¹的甲苯达唑（Meb）、300 mg·kg⁻¹·d⁻¹的阿苯达唑（Alb）或150 mg·kg⁻¹·d⁻¹的阿苯达唑亚砜（AlbSO）灌胃给药1 - 7天。各药物组囊壁糖原含量分别为1.0±0.6 - 1.8±0.9 mg/g、1.1±0.9 -
