Groenink L, Van der Gugten J, Verdouw P M, Maes R A, Olivier B
Department of Psychopharmacology, Faculty of Pharmacy, Rudolf Magnus Institute for Neurosciences, Utrecht University, Netherlands.
Eur J Pharmacol. 1995 Jul 4;280(2):185-93. doi: 10.1016/0014-2999(95)00209-4.
The effects of flesinoxan, a selective 5-HT1A receptor agonist, were studied under basal non-stress conditions and in the shock-probe burying paradigm. Flesinoxan (1 and 3 mg/kg s.c.) significantly reduced burying and freezing behaviour, indicating clear anxiolytic properties. Under non-stress conditions, injection of 3 mg/kg flesinoxan significantly enhanced plasma corticosterone and glucose levels, whereas prolactin secretion was significantly enhanced after both 1 mg/kg and 3 mg/kg flesinoxan. Flesinoxan (1 and 3 mg/kg) did not suppress shock-probe stress-induced rises in plasma corticosterone and glucose levels. The enhanced plasma prolactin levels induced by flesinoxan were not further affected by shock-probe exposure. Our data show that the anxiolytic effects of flesinoxan in the shock-probe burying paradigm are not related to increases in plasma corticosterone and glucose levels.
在基础非应激条件下以及在电击-探针埋埋范式中研究了选择性5-HT1A受体激动剂氟西诺生的作用。氟西诺生（1和3mg/kg皮下注射）显著减少了埋埋和僵住行为，表明具有明显的抗焦虑特性。在非应激条件下，注射3mg/kg氟西诺生显著提高了血浆皮质酮和葡萄糖水平，而在1mg/kg和3mg/kg氟西诺生注射后催乳素分泌均显著增加。氟西诺生（1和3mg/kg）并未抑制电击-探针应激诱导的血浆皮质酮和葡萄糖水平升高。氟西诺生诱导的血浆催乳素水平升高并未因电击-探针暴露而进一步受到影响。我们的数据表明，氟西诺生在电击-探针埋埋范式中的抗焦虑作用与血浆皮质酮和葡萄糖水平的升高无关。
