Groenink L, van der Gugten J, Zethof T J, van der Heyden J A, Olivier B
Department of Psychopharmacology, Faculty of Pharmacy, Utrecht University, The Netherlands.
Pharmacol Biochem Behav. 1996 May;54(1):249-54. doi: 10.1016/0091-3057(95)02177-9.
In the stress-induced hyperthermia (SIH) paradigm in mice, both a benzodiazepine receptor agonist, diazepam, and a 5-HT1A receptor agonist, flesinoxan, reduced the stress-induced increase in rectal temperature. The SIH procedure itself enhanced plasma ACTH and corticosterone levels but not plasma glucose levels. Diazepam (3, 6, and 12 mg/kg p.o.) did neither affect basal plasma ACTH, corticosterone, or glucose levels, nor did it suppress the stress-induced rises in these parameters. Flesinoxan (1, 3, and 10 mg/kg p.o.) enhanced plasma ACTH and corticosterone concentrations under nonstress conditions but did not affect the stress-induced increases in ACTH and corticosterone secretion. No clear effects of flesinoxan on plasma glucose levels were found. Our results indicate that in mice the anxiolytic effects of diazepam and flesinoxan in the SIH paradigm are not paralleled by a blockade of stress-induced increases in plasma ACTH, corticosterone, and glucose levels.
在小鼠应激诱导的体温过高（SIH）模型中，苯二氮䓬受体激动剂地西泮和5-HT1A受体激动剂氟司必林均可降低应激诱导的直肠温度升高。SIH程序本身会提高血浆促肾上腺皮质激素（ACTH）和皮质酮水平，但不会提高血浆葡萄糖水平。地西泮（3、6和12mg/kg口服）既不影响基础血浆ACTH、皮质酮或葡萄糖水平，也不抑制应激诱导的这些参数升高。氟司必林（1、3和10mg/kg口服）在非应激条件下会提高血浆ACTH和皮质酮浓度，但不影响应激诱导的ACTH和皮质酮分泌增加。未发现氟司必林对血浆葡萄糖水平有明显影响。我们的结果表明，在小鼠中，地西泮和氟司必林在SIH模型中的抗焦虑作用与阻断应激诱导的血浆ACTH、皮质酮和葡萄糖水平升高并不平行。
