Reynolds G P, Mason S L
Department of Biomedical Science, University of Sheffield, UK.
Eur J Pharmacol. 1995 Aug 4;281(2):R5-6. doi: 10.1016/0014-2999(95)00408-d.
The difference between saturable binding of [3H]emonapride (to D2, D3 and D4 receptors) and [125I]epidepride (to D2 and D3 receptors) was used to determine dopamine D4 receptors in putamen taken post-mortem from antipsychotic-treated schizophrenic subjects and matched controls. Despite an overall increase in D2/D3 receptor density in schizophrenia, reflecting prior antipsychotic drug treatment, striatal D4 receptors were not significantly detectable in either controls or schizophrenic subjects.
利用[3H]依莫必利（作用于D2、D3和D4受体）与[125I]表哌必利（作用于D2和D3受体）的饱和结合差异，来测定死后取自接受抗精神病药物治疗的精神分裂症患者及匹配对照者的壳核中的多巴胺D4受体。尽管精神分裂症患者中D2/D3受体密度总体增加，这反映了之前的抗精神病药物治疗，但在对照组或精神分裂症患者中均未显著检测到纹状体D4受体。
