精神分裂症患者大脑中σ降低，但纹状体多巴胺D4位点未增加。

Decrease in sigma but no increase in striatal dopamine D4 sites in schizophrenic brains.

作者信息

Helmeste D M, Tang S W, Bunney W E, Potkin S G, Jones E G

机构信息

Department of Psychiatry, University of California at Irvine, 92697, USA.

出版信息

Eur J Pharmacol. 1996 Oct 31;314(3):R3-5. doi: 10.1016/s0014-2999(96)00702-9.

DOI:10.1016/s0014-2999(96)00702-9

PMID:8957266

Abstract

[3H]Nemonapride differentially defines sigma and dopamine receptor sites depending upon assay conditions. In post-mortem schizophrenic brain tissues, [3H]nemonapride-labeled sigma receptor binding is decreased compared to match normal controls. No striatal dopamine D4/D4-like receptor differential was observed between the schizophrenic or control tissues, using the [3H]nemonapride minus [3H]raclopride subtraction method.

摘要

根据检测条件，[3H]奈莫必利对σ受体和多巴胺受体位点的界定不同。在尸检的精神分裂症脑组织中，与匹配的正常对照相比，[3H]奈莫必利标记的σ受体结合减少。使用[3H]奈莫必利减去[3H]雷氯必利的扣除法，在精神分裂症组织或对照组织之间未观察到纹状体多巴胺D4/D4样受体差异。