Tomasetto C, Moog-Lutz C, Régnier C H, Schreiber V, Basset P, Rio M C
Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/U184 INSERM/ULP, Illkirch, France.
FEBS Lett. 1995 Oct 16;373(3):245-9. doi: 10.1016/0014-5793(95)01040-l.
MLN 50 was previously identified in a cDNA library of breast cancer metastasis. In this study, we show that MLN 50, which is expressed at a basal level in normal tissues, is overexpressed in 8% of human breast carcinomas most often together with c-erbB-2. MLN 50 cDNA encodes a putative protein of 261 residues, named Lasp-1 (LIM and SH3 protein) since it contains a LIM motif and a domain of Src homology region 3 (SH3) at the amino- and the C-terminal parts of the protein, respectively. Thus, Lasp-1 defines a new LIM protein subfamily.
MLN 50先前是在乳腺癌转移的cDNA文库中被鉴定出来的。在本研究中，我们发现，MLN 50在正常组织中呈基础水平表达，在8%的人类乳腺癌中过度表达，且大多与c-erbB-2共同表达。MLN 50 cDNA编码一个含261个残基的推定蛋白，命名为Lasp-1（LIM和SH3蛋白），因为该蛋白在氨基端和羧基端分别含有一个LIM基序和一个Src同源区3（SH3）结构域。因此，Lasp-1定义了一个新的LIM蛋白亚家族。
