Slominski A, Ermak G, Hwang J, Chakraborty A, Mazurkiewicz J E, Mihm M
Department of Pathology and Laboratory Medicine, Albany Medical College, NY 12208, USA.
FEBS Lett. 1995 Oct 23;374(1):113-6. doi: 10.1016/0014-5793(95)01090-2.
Evidence is provided that human skin, the largest body organ exposed to multiple stressors, expresses proopiomelanocortin (POMC), corticotropin releasing hormone (CRH) and CRH-receptor (CRHR) genes in vivo. In vitro studies show that POMC and CRHR mRNAs are transcribed in melanocytes, cells derived from the neural crest, and in keratinocytes, cells derived from the ectoderm. CRH mRNA is transcribed in cultured melanocytes but not in keratinocytes. It is proposed that an equivalent of the 'hypothalamus-pituitary axis' composed of the CRH-CRHR-POMC loop is conserved in mammalian skin.
有证据表明，人体最大的器官皮肤暴露于多种应激源下，在体内表达阿黑皮素原（POMC）、促肾上腺皮质激素释放激素（CRH）和CRH受体（CRHR）基因。体外研究表明，POMC和CRHR mRNA在黑素细胞（源自神经嵴的细胞）和角质形成细胞（源自外胚层的细胞）中被转录。CRH mRNA在培养的黑素细胞中被转录，但在角质形成细胞中不被转录。有人提出，由CRH - CRHR - POMC环组成的相当于“下丘脑 - 垂体轴”的结构在哺乳动物皮肤中是保守的。
