Sauvant M P, Pepin D, Bohatier J
Faculté de Pharmacie, Laboratoire d'Hydrologie et Hygiène, Clermont-Ferrand, France.
Food Addit Contam. 1995 Jul-Aug;12(4):567-84. doi: 10.1080/02652039509374345.
This study proposed a new strategy assessing the health risks of mineral water packaging and compared the chemical analytical techniques and some in vitro cytotoxicological assays for the study of PVC and PET materials at the main stages of the manufacturing process of bottles. These evaluations were carried out with food simulant (deionized-endotoxin-tested water) and with natural mineral water in real conditions of packaging and storage (from 0 to 24 months). The complementarity of these two approaches is discussed. Some analytical and cytotoxic abnormalities were detected in the food simulant after contact with the batches of powdered PVC compound, PET resin and their intermediate steps of transformation (PVC-'paraison', PET-'perform'). But these results did not reflect the actual behaviour of the finished PVC and PET bottles, for which no major abnormality was detected in the natural mineral water.
本研究提出了一种评估矿泉水包装健康风险的新策略，并比较了在瓶子制造过程主要阶段研究聚氯乙烯（PVC）和聚对苯二甲酸乙二酯（PET）材料的化学分析技术和一些体外细胞毒性试验。这些评估是使用食品模拟物（去离子-内毒素检测水）以及在包装和储存的实际条件下（0至24个月）使用天然矿泉水进行的。讨论了这两种方法的互补性。在与一批批粉状PVC化合物、PET树脂及其转化中间步骤（PVC-“预聚物”、PET-“预成型坯”）接触后的食品模拟物中检测到了一些分析和细胞毒性异常。但这些结果并未反映成品PVC和PET瓶的实际行为，在天然矿泉水中未检测到这些成品瓶有重大异常。
