文献检索，用中文搜 PubMed

Suppr 超能文献

核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Glavin G B, Hall A M

Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, Winnipeg, Canada.

Gen Pharmacol. 1995 Oct;26(6):1277-9. doi: 10.1016/0306-3623(95)00009-p.

Dopamine D1 (central)/DA1 (peripheral) receptors are believed to influence gastrointestinal function and pathology. 2. When given i.c.v. or i.p., an agonist (SKF38393) and an antagonist (SCH23390) of this DA receptor subtype inhibit and enhance, respectively, gastric secretion and gastric mucosal injury. 3. When given both i.c.v. and i.p., their respective effects in the gut were amplified. 4. Antagonist or agonist given i.p., blocked the corresponding protective and worsening effect of the agonist or antagonist given i.c.v. 5. Both central and peripheral D1/DA1 receptors modulate gastric function and response to injury.

多巴胺D1（中枢）/DA1（外周）受体被认为会影响胃肠功能和病理状态。2. 当通过脑室内或腹腔内给药时，该多巴胺受体亚型的激动剂（SKF38393）和拮抗剂（SCH23390）分别抑制和增强胃分泌及胃黏膜损伤。3. 当同时进行脑室内和腹腔内给药时，它们在肠道中的各自作用会被放大。4. 腹腔内给予拮抗剂或激动剂，会阻断脑室内给予激动剂或拮抗剂的相应保护和恶化作用。5. 中枢和外周的D1/DA1受体均调节胃功能及对损伤的反应。

Glavin G B, Hall A M

Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, Winnipeg, Canada.

Gen Pharmacol. 1995 Oct;26(6):1277-9. doi: 10.1016/0306-3623(95)00009-p.

Dopamine D1 (central)/DA1 (peripheral) receptors are believed to influence gastrointestinal function and pathology. 2. When given i.c.v. or i.p., an agonist (SKF38393) and an antagonist (SCH23390) of this DA receptor subtype inhibit and enhance, respectively, gastric secretion and gastric mucosal injury. 3. When given both i.c.v. and i.p., their respective effects in the gut were amplified. 4. Antagonist or agonist given i.p., blocked the corresponding protective and worsening effect of the agonist or antagonist given i.c.v. 5. Both central and peripheral D1/DA1 receptors modulate gastric function and response to injury.

多巴胺D1（中枢）/DA1（外周）受体被认为会影响胃肠功能和病理状态。2. 当通过脑室内或腹腔内给药时，该多巴胺受体亚型的激动剂（SKF38393）和拮抗剂（SCH23390）分别抑制和增强胃分泌及胃黏膜损伤。3. 当同时进行脑室内和腹腔内给药时，它们在肠道中的各自作用会被放大。4. 腹腔内给予拮抗剂或激动剂，会阻断脑室内给予激动剂或拮抗剂的相应保护和恶化作用。5. 中枢和外周的D1/DA1受体均调节胃功能及对损伤的反应。