地尔硫䓬和维拉帕米对二磷酸腺苷诱导的兔血小板形状改变和聚集的影响。

Effects of diltiazem and verapamil on ADP-induced rabbit platelet shape change and aggregation.

Dehpour A R, Samadian T, Akhavan M M, Meysamee F, Delfan A

Department of Pharmacology, Faculty of Medicine, Tehran University of Medical Sciences, Iran.

Gen Pharmacol. 1995 Oct;26(6):1295-9. doi: 10.1016/0306-3623(95)00002-i.

Abstract

The effects of diltiazem and verapamil (two structurally different calcium channel blockers) were examined on the rabbit platelets shape change and aggregation induced by adenosine-5'-diphosphate (ADP). 2. ADP was a much more potent stimulator on inducing platelet shape change (ED50 = 1 x 10(-7)) than platelet aggregation (ED50 = 1.78 x 10(-6)). 3. Both drugs similarly inhibited ADP-induced platelet shape change and aggregation at concentrations more than 300 microM. 4. There were no significant differences in inhibitory effects of either diltiazem or verapamil on ADP-induced platelet shape change and aggregation. 5. The inhibitory effects of diltiazem and verapamil on ADP-induced platelet shape change and aggregation at high concentrations may be due to their non specific properties.

摘要

研究了地尔硫䓬和维拉帕米（两种结构不同的钙通道阻滞剂）对腺苷-5'-二磷酸（ADP）诱导的兔血小板形态变化和聚集的影响。2. ADP在诱导血小板形态变化（半数有效浓度[ED50]=1×10⁻⁷）方面比诱导血小板聚集（ED50=1.78×10⁻⁶）更有效。3. 两种药物在浓度高于300微摩尔时均同样抑制ADP诱导的血小板形态变化和聚集。4. 地尔硫䓬或维拉帕米对ADP诱导的血小板形态变化和聚集的抑制作用无显著差异。5. 地尔硫䓬和维拉帕米在高浓度时对ADP诱导的血小板形态变化和聚集的抑制作用可能归因于它们的非特异性特性。