Bulaeva K B, Pavlova T A, Bodia I E, Guseĭnov G G, Charukhilova S M
Genetika. 1995 Aug;31(8):1154-62.
The results of a genetic and demographic study of two "split" isolates of small native ethnic groups of Daghestan are described. Parts of these populations were resettled from habitual highland ecological conditions to radically new lowland conditions in the 1940s. These split isolates were compared with a population of native inhabitants of the Daghestan lowland. It was found that, since resettling, separated populations originating from split isolates became significantly different in both marriage and genetic structures. This is manifested in different phenotypic and allelic frequencies of a number of physiological and biochemical markers and in levels of their heterozygosity. To explain the differences revealed, a hypothesis was proposed about the relationship between levels of inbreeding, heterozygosity, and physiologic sensitivity that account for the differential adaptability of members of the isolated populations to changing environmental conditions. This is the first report of a series of papers describing the experimental testing of this hypothesis. While testing the validity of the hypothesis in this study, a positive linear correlation was found between inbreeding and homozygosity levels.
本文描述了对达吉斯坦两个小型本土少数民族“分裂”隔离群体的遗传和人口学研究结果。这些群体的部分人口在20世纪40年代从惯常的高地生态环境迁移到全新的低地环境。将这些分裂隔离群体与达吉斯坦低地的本土居民群体进行了比较。研究发现，自迁移以来，源自分裂隔离群体的分离群体在婚姻和遗传结构上都出现了显著差异。这体现在一些生理和生化标志物的不同表型和等位基因频率以及它们的杂合度水平上。为了解释所揭示的差异，提出了一个关于近亲繁殖水平、杂合度和生理敏感性之间关系的假说，该假说解释了隔离群体成员对不断变化的环境条件的不同适应能力。这是一系列描述该假说实验验证的论文中的第一篇报告。在本研究中检验该假说的有效性时，发现近亲繁殖水平与纯合度之间存在正线性相关。
