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达吉斯坦(位于高加索地区)的种族基因组多样性。

Ethnogenomic diversity of Caucasus, Daghestan.

作者信息

Bulayeva K B, Jorde L, Watkins S, Ostler C, Pavlova T A, Bulayev O A, Tofanelli S, Paoli G, Harpending H

机构信息

N.I. Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow 117991, Russia.

出版信息

Am J Hum Biol. 2006 Sep-Oct;18(5):610-20. doi: 10.1002/ajhb.20531.

DOI:10.1002/ajhb.20531
PMID:16917895
Abstract

Autosomal short-tandem repeats (STRs) were typed in ethnic populations of Kubachians, Dargins, Avars, Lezgins, Kumiks, and Nogais of the Caucasus (Daghestan, Russia) at the University of Utah. Daghestan ethnic populations demonstrated differences in STR allele frequency distributions, but these differences were much lower among these ethnic groups compared to worldwide ethnic groups. The observed genetic diversity was low while F(ST) values were high, both of which provided supporting evidence for small population sizes and high levels of isolation among the ethnic groups. An analysis of genetic distance from the three major continents, encompassing Daghestan populations and groups, reveals three distinct clusters: all populations of African affiliation, European and Daghestan populations except the Nogais, and Asian populations with ethnic Nogais.

摘要

在犹他大学对俄罗斯达吉斯坦(位于高加索地区)的库巴奇人、达尔金人、阿瓦尔人、列兹金人、库梅克人和诺盖人的种族群体进行了常染色体短串联重复序列(STR)分型。达吉斯坦的种族群体在STR等位基因频率分布上存在差异,但与世界范围内的种族群体相比,这些种族群体之间的差异要小得多。观察到的遗传多样性较低,而F(ST)值较高,这两者都为种群规模小和种族群体之间高度隔离提供了支持证据。对包括达吉斯坦种群和群体在内的来自三大洲的遗传距离分析揭示了三个不同的聚类:所有非洲裔种群、除诺盖人之外的欧洲和达吉斯坦种群,以及包含诺盖人的亚洲种群。

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