Ehrsson H, Nilsson S O, Ehrnebo M, Wallin I, Wennersten G
Clin Pharmacol Ther. 1979 Feb;25(2):167-71. doi: 10.1002/cpt1979252167.
Kinetics of 8-methoxsalen were studied in 5 healthy subjects under fasting and nonfasting conditions. The plasma concentration-time data could be fitted to a zero order absorption one-compartment model. The area under the curve (AUC) values were higher (p less than 0.05) under nonfasting compared to fasting conditions, indicating higher relative bioavailability of the drug in the presence of food. No significant differences were observed in the lag-time for the start of the absorption, the apparent zero-order absorption rate constant, or the elimination rate constant. It is suggested that the drug should be taken in a standardized way in relation to food during the ultraviolet (UV) light treatment.
在5名健康受试者中研究了8-甲氧基补骨脂素在禁食和非禁食条件下的动力学。血浆浓度-时间数据可拟合为零级吸收单室模型。与禁食条件相比，非禁食条件下的曲线下面积（AUC）值更高（p<0.05），表明食物存在时药物的相对生物利用度更高。在吸收开始的滞后时间、表观零级吸收速率常数或消除速率常数方面未观察到显著差异。建议在紫外线（UV）光疗期间，药物应与食物以标准化方式服用。
