伯氏疏螺旋体的外表面脂蛋白A为CD4+和CD8+ T细胞的激活提供直接和间接的增强/共刺激信号。 - Suppr | 超能文献

The outer surface lipoprotein A of Borrelia burgdorferi provides direct and indirect augmenting/co-stimulatory signals for the activation of CD4+ and CD8+ T cells.

作者信息

Simon M M, Nerz G, Kramer M D, Hurtenbach U, Schaible U E, Wallich R

机构信息

Max-Planck-Institut für Immunbiologie, Freiburg, Germany.

出版信息

Immunol Lett. 1995 Jun;46(3):137-42.

Abstract

摘要

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The outer surface lipoprotein A of Borrelia burgdorferi provides direct and indirect augmenting/co-stimulatory signals for the activation of CD4+ and CD8+ T cells.伯氏疏螺旋体的外表面脂蛋白A为CD4+和CD8+ T细胞的激活提供直接和间接的增强/共刺激信号。

Immunol Lett. 1995 Jun;46(3):137-42.

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The outer surface lipoprotein OspA of Borrelia burgdorferi provides co-stimulatory signals to normal human peripheral CD4+ and CD8+ T lymphocytes.伯氏疏螺旋体的外表面脂蛋白OspA为正常人外周血CD4+和CD8+ T淋巴细胞提供共刺激信号。

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The outer surface lipoprotein A of Borrelia burgdorferi provides direct and indirect augmenting/co-stimulatory signals for the activation of CD4+ and CD8+ T cells.伯氏疏螺旋体的外表面脂蛋白A为CD4+和CD8+ T细胞的激活提供直接和间接的增强/共刺激信号。

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Detection of Borrelia burgdorferi-specific CD8+ cytotoxic T cells in patients with Lyme arthritis.莱姆关节炎患者中伯氏疏螺旋体特异性CD8 + 细胞毒性T细胞的检测。

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Borrelia burgdorferi outer membrane protein A induces nuclear translocation of nuclear factor-kappa B and inflammatory activation in human endothelial cells.伯氏疏螺旋体外膜蛋白A诱导人内皮细胞核因子-κB的核转位及炎症激活。

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Borrelia burgdorferi outer surface lipoproteins OspA and OspB possess B-cell mitogenic and cytokine-stimulatory properties.伯氏疏螺旋体外膜脂蛋白OspA和OspB具有B细胞促有丝分裂和细胞因子刺激特性。

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Borrelia burgdorferi activates nuclear factor-kappa B and is a potent inducer of chemokine and adhesion molecule gene expression in endothelial cells and fibroblasts.伯氏疏螺旋体激活核因子-κB，并且是内皮细胞和成纤维细胞中趋化因子和黏附分子基因表达的有效诱导剂。

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The lipid component of lipoproteins from Borrelia burgdorferi: structural analysis, antigenicity, and presentation via human dendritic cells.伯氏疏螺旋体脂蛋白的脂质成分：结构分析、抗原性及通过人树突状细胞的呈递

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Outer surface lipoproteins of Borrelia burgdorferi stimulate nitric oxide production by the cytokine-inducible pathway.伯氏疏螺旋体的外表面脂蛋白通过细胞因子诱导途径刺激一氧化氮的产生。

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引用本文的文献

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Dominant recognition of a Borrelia burgdorferi outer surface protein A peptide by T helper cells in patients with treatment-resistant Lyme arthritis.治疗抵抗性莱姆关节炎患者的T辅助细胞对伯氏疏螺旋体外膜蛋白A肽的显性识别

Infect Immun. 1996 Apr;64(4):1284-9. doi: 10.1128/iai.64.4.1284-1289.1996.