脱氧胆酸钠促进猪肠道中志贺毒素2e的全身吸收。
Sodium deoxycholate facilitates systemic absorption of verotoxin 2e from pig intestine.
作者信息
Waddell T E, Gyles C L
机构信息
Department of Veterinary Microbiology and Immunology, Ontario Veterinary College, University of Guelph, Canada.
出版信息
Infect Immun. 1995 Dec;63(12):4953-6. doi: 10.1128/iai.63.12.4953-4956.1995.
Abstract
Injection of verotoxin 2e together with sodium deoxycholate, which increases intestinal permeability to macromolecules, into the intestine of pigs resulted in fluid accumulation, intestinal damage, and signs and lesions of edema disease. Intragastric administration of verotoxin 2e to newborn piglets, who normally absorb protein nonspecifically, resulted in systemic verotoxemia. These results suggest that development of natural edema disease requires a state of increased intestinal permeability.
摘要
将维罗毒素2e与脱氧胆酸钠一起注射到猪的肠道中（脱氧胆酸钠可增加肠道对大分子的通透性），会导致液体蓄积、肠道损伤以及水肿病的症状和病变。给通常非特异性吸收蛋白质的新生仔猪胃内给予维罗毒素2e，会导致全身性维罗毒素血症。这些结果表明，自然水肿病的发生需要肠道通透性增加的状态。
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