Nakada T, Kaneko H, Kubota Y, Watanabe M, Sasagawa I, Yagisawa T, Yamanaka H, Imai K
Department of Urology, Yamagata University, School of Medicine, Japan.
Int Urol Nephrol. 1995;27(2):121-30. doi: 10.1007/BF02551307.
Sequential changes in creatinine clearance (Ccr) were determined in 14 patients undergoing operation for phaeochromocytoma. All patients had been given alpha-adrenergic antagonists 2 weeks before surgery. In the younger group (mean age 40 +/- 2 years), Ccr improved following adrenal surgery. Urinary concentrations of epinephrine, norepinephrine and total catecholamines correlated inversely with Ccr. A similar inverse relationship was noted between tissue norepinephrine concentration expressed as microgram/g and Ccr to a lesser extent. In older patients (mean age 69 +/- 2 years) Ccr remained unchanged by this surgical procedure. No significant correlations were found between both parameters in the older group. It appears reasonable to presume that excessive amount of catecholamine plays an important role in the impairment of Ccr in relatively young patients with phaeochromocytoma, but other possibilities as regards the sequence of this phenomenon must be pursued in older patients.
对14例接受嗜铬细胞瘤手术的患者测定了肌酐清除率（Ccr）的连续变化。所有患者在手术前2周均给予了α-肾上腺素能拮抗剂。在较年轻组（平均年龄40±2岁），肾上腺手术后Ccr有所改善。尿中肾上腺素、去甲肾上腺素和总儿茶酚胺的浓度与Ccr呈负相关。以微克/克表示的组织去甲肾上腺素浓度与Ccr之间也存在类似的负相关，但程度较小。在老年患者（平均年龄69±2岁）中，该手术过程对Ccr没有影响。老年组中这两个参数之间未发现显著相关性。可以合理推测，在相对年轻的嗜铬细胞瘤患者中，过量的儿茶酚胺在Ccr受损中起重要作用，但对于老年患者，必须探讨这种现象发生顺序的其他可能性。
