Nolte D, Berger D, Förster E
Dtsch Med Wochenschr. 1979 Feb 2;104(5):172-4. doi: 10.1055/s-0028-1103865.
25 asthma patients regularly showed an increase in respiratory resistance, as measured by the oscillation method, after propellant from a dosage aerosol had been sprayed into their buccal or nasal cavity. This effect, which was also seen in three laryngectomised patients, could be blocked by ipratropium bromide, an anticholinergic agent. Evidently it is due to a bronchoconstrictor reflex elicited by the local low-temperature stimulus produced by the propellant.
25名哮喘患者在将定量气雾剂的推进剂喷入口腔或鼻腔后，通过振荡法测量，其呼吸阻力经常会增加。这种效应在3名喉切除患者中也可见到，可被抗胆碱能药物异丙托溴铵阻断。显然，这是由推进剂产生的局部低温刺激引发的支气管收缩反射所致。
