Nolte D, Berger D
Eur J Respir Dis Suppl. 1983;128 (Pt 1):110-5.
In 27 asthmatic patients a single cold stimulus into the nose resulted in a sudden increase of airway resistance, measured continuously by a forced-oscillation technique. The effect could be blocked by previous intrabronchial application of an anticholinergic drug. In laryngectomised patients, who no longer have a connection between the upper and the lower airways, a cold stimulus into the nose also caused bronchoconstriction. So the cold effect must be based on a reflex mechanism.
在27例哮喘患者中，通过强迫振荡技术连续测量发现，向鼻腔内单次施加冷刺激会导致气道阻力突然增加。预先在支气管内应用抗胆碱能药物可阻断这种效应。在已行喉切除术的患者中，其上下呼吸道不再相连，向鼻腔内施加冷刺激也会引起支气管收缩。因此，这种冷刺激效应一定是基于一种反射机制。
