Köhler L D, Kautzky F, Vogt H J
Dermatologische Klinik und Poliklinik, Technischen Universität, München.
Hautarzt. 1995 Sep;46(9):638-42. doi: 10.1007/s001050050311.
We report on a 56-year-old renal allograft recipient receiving cyclosporin A immunosuppression. During this therapy he subsequently developed the following cutaneous neoplasms: squamous cell carcinomas, basal cell carcinomas, Bowen's disease, actinic keratosis, sebaceous hyperplasia, a dysplastic naevus and, finally a nodular malignant melanoma. Adverse effects of the cyclosporin A therapy are discussed, with special reference to dermatologic effects and the implications for patient and doctor.
我们报告了一名接受环孢素A免疫抑制治疗的56岁肾移植受者。在此治疗期间,他随后出现了以下皮肤肿瘤:鳞状细胞癌、基底细胞癌、鲍温病、光化性角化病、皮脂腺增生、发育异常痣,最后还有结节性恶性黑色素瘤。本文讨论了环孢素A治疗的不良反应,特别提及了皮肤方面的影响以及对患者和医生的启示。