Aloi F, Mödl G, Solaroli C
Hautklinik, Universität, Turin, Italien.
Hautarzt. 1995 Sep;46(9):656-9. doi: 10.1007/s001050050315.
A 58-year-old man presented with a solitary, asymptomatic, firm nodular lesion on his glans. A simple excision was carried out. Follow-up for 1 year failed to reveal either recurrence or metastases. Histologically, there was intradermal proliferation of atypical oval and spindle-shaped cells arranged in fascicles simulating the pattern of neural tumours. Mitotic figures were abundant. Stains for melanin, HMB-45 antigen were negative. Immunohistochemically, tumour cells stained for S-100 protein and vimentin. Malignant schwannoma usually occurs in patients with neurofibromatosis and is located in the subcutaneous tissues. Solitary malignant schwannoma of superficial soft tissue is a rare entity, and there are problems of differential diagnosis against other spindle cell tumours, especially malignant spindle cell melanoma. Their appearance on the glans is rare.
一名58岁男性患者，龟头出现一个孤立的、无症状的、质地坚硬的结节性病变。进行了简单切除。随访1年未发现复发或转移。组织学上，真皮内有非典型椭圆形和梭形细胞呈束状增生，模拟神经肿瘤的模式。有丰富的核分裂象。黑色素、HMB - 45抗原染色均为阴性。免疫组化显示，肿瘤细胞S - 100蛋白和波形蛋白染色阳性。恶性神经鞘瘤通常发生于神经纤维瘤病患者，位于皮下组织。浅表软组织孤立性恶性神经鞘瘤是一种罕见的实体，与其他梭形细胞肿瘤，尤其是恶性梭形细胞黑色素瘤存在鉴别诊断问题。其出现在龟头上很罕见。
