Hagihara M, Shimura T, Sato K, Genga K, Suzuki M, Tsuji K
Department of Transplantation Immunology, Tokai University School of Medicine, Kanagawa, Japan.
Hum Immunol. 1995 Jun;43(2):95-100. doi: 10.1016/0198-8859(94)00154-i.
The frequencies of HLA class I and II antigens and TNF-beta polymorphism in lung cancer patients were investigated in two areas with different immunogenetic backgrounds, in Okinawa and in mainland Japan (Honshu). In Okinawa frequencies of HLA-Cw3 in squamous cell lung carcinoma patients were higher and those of HLA-DR, both in all lung cancer and in adeno lung carcinoma patients, were lower compared to those of normal controls. Among serologic HLA-DR4-positive individuals, no difference of DRB1*04 gene allele frequency was shown between patients and controls. In Honshu no statistically significant difference of HLA-class I and II alleles frequencies was found; however, the frequency of TNF-beta 10.5-kb homozygote in lung cancer patients was lower than that of controls. For 2-year survival, there was no difference between DR4-positive and -negative individuals and also between each TNF-beta type in Okinawa. In contrast, Honshu patients with 10.5-kb homozygote showed an improved 5-year survival ratio compared to those with heterozygote. We postulate that different immunogenetic backgrounds or environments might have caused the varying HLA or TNF-beta association in the predisposition to or prognosis of lung cancer.
在日本冲绳和本州两个具有不同免疫遗传背景的地区，对肺癌患者的HLA I类和II类抗原频率以及TNF-β多态性进行了研究。在冲绳，与正常对照组相比，鳞状细胞肺癌患者中HLA-Cw3的频率较高，而在所有肺癌患者和腺癌患者中HLA-DR的频率较低。在血清学HLA-DR4阳性个体中，患者和对照组之间未显示出DRB1*04基因等位基因频率的差异。在本州，未发现HLA I类和II类等位基因频率有统计学意义的差异；然而，肺癌患者中TNF-β 10.5-kb纯合子的频率低于对照组。在冲绳，DR4阳性和阴性个体之间以及每种TNF-β类型之间的2年生存率没有差异。相比之下，本州10.5-kb纯合子的患者与杂合子患者相比，5年生存率有所提高。我们推测，不同的免疫遗传背景或环境可能导致肺癌易感性或预后中HLA或TNF-β关联的差异。
