Shimura T, Hagihara M, Takebe K, Munkhbat B, Odaka T, Kato H, Nagamachi Y, Tsuji K
Department of Transplantation Immunology, Tokai University School of Medicine, Kanagawa, Japan.
Cancer. 1994 Feb 15;73(4):1184-8. doi: 10.1002/1097-0142(19940215)73:4<1184::aid-cncr2820730410>3.0.co;2-y.
In recent years numerous reports have discussed the relationship between the human leukocyte antigen and lung cancer. However, the genetic background of lung cancer has not yet been precisely clarified.
To investigate the genetic background of lung cancer, the human leukocyte antigens in 159 normal healthy control subjects and 102 lung cancer patients were studied, and restriction fragment length polymorphism analysis of the tumor necrosis factor (TNF) beta gene in 165 normal healthy control subjects and 135 lung cancer patients was performed.
Lung cancer patients showed a high frequency of human leukocyte antigen B61; however, no statistical difference was found. In the lung cancer patients, the TNF beta 10.5/10.5-kb allele was found at a low frequency, 38.5%, compared to 53.3% in normal controls (chi 2 = 7.51, P = 0.011, corrected P = 0.033, relative risk = 0.77). In the relationship between the histologic types and the TNF beta gene, the TNF beta 10.5/10.5-kb allele showed low frequencies: 38.5% in adenocarcinoma, 38.2% in squamous cell carcinoma, and 27.8% in small cell carcinoma, although no statistical difference was shown. In relation to the postoperative survival period, the TNF beta 10.5/10.5-kb allele was associated with prolonged survival.
The TNF beta 10.5/10.5-kb allele may be associated with resistance to lung cancer and with a better prognosis.
近年来，众多报告探讨了人类白细胞抗原与肺癌之间的关系。然而，肺癌的遗传背景尚未得到确切阐明。
为研究肺癌的遗传背景，对159名正常健康对照者和102名肺癌患者的人类白细胞抗原进行了研究，并对165名正常健康对照者和135名肺癌患者的肿瘤坏死因子（TNF）β基因进行了限制性片段长度多态性分析。
肺癌患者中人类白细胞抗原B61的频率较高，但未发现统计学差异。在肺癌患者中，TNFβ 10.5/10.5-kb等位基因的频率较低，为38.5%，而正常对照者中的频率为53.3%（χ² = 7.51，P = 0.011，校正P = 0.033，相对风险 = 0.77）。在组织学类型与TNFβ基因的关系中，TNFβ 10.5/10.5-kb等位基因的频率较低：腺癌中为38.5%，鳞状细胞癌中为38.2%，小细胞癌中为27.8%，尽管未显示出统计学差异。关于术后生存期，TNFβ 10.5/10.5-kb等位基因与生存期延长相关。
TNFβ 10.5/10.5-kb等位基因可能与肺癌耐药性及较好的预后相关。
