Irschik H, Augustiniak H, Gerth K, Höfle G, Reichenbach H
GBF, Gesellschaft für Biotechnologische Forschung, Department of Biology of Natural Products, Braunschweig, Germany.
J Antibiot (Tokyo). 1995 Aug;48(8):787-92. doi: 10.7164/antibiotics.48.787.
A new antibiotic, ripostatin, was isolated from the culture supernatant of the myxobacterium, sorangium cellulosum strain So ce377. It is a macrocyclic lactone carbonic acid containing an unsubstituted phenyl ring in a side chain. The antibiotic acts especially on Staphylococcus aureus, but seems not to penetrate most bacteria. The MIC values are in the range of 1 microgram/ml. Ripostatin is an inhibitor of eubacterial RNA polymerase. It interferes with the initiation of RNA synthesis.
一种新型抗生素——瑞波他汀，是从粘细菌纤维素堆囊菌菌株So ce377的培养上清液中分离得到的。它是一种大环内酯碳酸，其侧链含有一个未被取代的苯环。这种抗生素对金黄色葡萄球菌有特效，但似乎无法穿透大多数细菌。其最低抑菌浓度值在1微克/毫升范围内。瑞波他汀是真细菌RNA聚合酶的抑制剂，它会干扰RNA合成的起始过程。
