Massari V J, Tizabi Y, Jacobowitz D M
Exp Brain Res. 1979 Jan 2;34(1):177-82. doi: 10.1007/BF00238350.
Pharmacological and morphological evidence suggests that the functional activity of serotonergic neurons may be regulated by catecholamines. We have attempted to reveal a potential pathway by which this interaction might occur. Rats received bilateral knife cut lesions of the ventral noradrenergic bundle which severed the A-1 and A-2 cell body contributions to this projection. Controls received a sham lesion into the cerebellum. Two weeks later all animals were sacrificed, and norepinephrine and serotonin levels were measured in discrete nuclei of the brain. Lesion placement was confirmed histofluorometrically. Serotonin levels in the median raphe nucleus were significantly reduced by 40%, but levels of serotonin were unaffected in the dorsal raphe nucleus and 8 serotonergic terminal regions. The lesions did not affect levels of norepinephrine in the locus coeruleus, cingulate cortex, or habenula. This study suggests that a noradrenergic projection to the median raphe nucleus from the A-1 and A-2 cell body groups may modulate serotonergic neuronal function.
药理学和形态学证据表明，血清素能神经元的功能活性可能受儿茶酚胺调节。我们试图揭示这种相互作用可能发生的潜在途径。给大鼠双侧切断腹侧去甲肾上腺素能束，切断A-1和A-2细胞体对该投射的贡献。对照组在小脑进行假损伤。两周后处死所有动物，测量脑内离散核中的去甲肾上腺素和血清素水平。通过组织荧光测定法确认损伤位置。中缝核中的血清素水平显著降低了40%，但背侧中缝核和8个血清素能终末区域的血清素水平未受影响。这些损伤不影响蓝斑、扣带回皮质或缰核中的去甲肾上腺素水平。这项研究表明，从A-1和A-2细胞体组到中缝核的去甲肾上腺素能投射可能调节血清素能神经元功能。
