Hiles M C, Badylak S F, Lantz G C, Kokini K, Geddes L A, Morff R J
Hillenbrand Biomedical Engineering Center, Purdue University, W. Lafayette, Indiana 47907, USA.
J Biomed Mater Res. 1995 Jul;29(7):883-91. doi: 10.1002/jbm.820290714.
Small-intestinal submucosa (SIS) has been shown to induce tissue remodelling in vivo when used as a vascular graft. The present study investigated in physical and mechanical properties of remodeled aortic grafts derived from xenogeneic SIS material. Eight infrarenal aortic grafts were implanted in mongrel dogs. The grafts were explanted at 1 or 2 months and tested for compliance and hoop mechanical properties. The morphologic changes within the grafts were also characterized. The remodeling process produced graft structures which were significantly stronger than both the normal artery (P = .012) and the original SIS graft (P = .0001), and the compliance of these structures was one third that of normal artery and similar to the original SIS grafts. The remodeled grafts were > 10 times the thickness of the implanted SIS. Immunohistochemical analysis of remodeled tissues suggest that the SIS material was degraded and resorbed over time. The remodeling process transformed a material which was physically and mechanically quite different from normal aorta into a blood conduit which had the physical and mechanical properties needed to function in this mammalian arterial system.
小肠黏膜下层（SIS）作为血管移植物在体内已被证明可诱导组织重塑。本研究调查了源自异种SIS材料的重塑主动脉移植物的物理和力学性能。将8个肾下腹主动脉移植物植入杂种犬体内。在1或2个月时取出移植物，测试其顺应性和环向力学性能。还对移植物内的形态学变化进行了表征。重塑过程产生的移植物结构比正常动脉（P = 0.012）和原始SIS移植物（P = 0.0001）都明显更强，并且这些结构的顺应性是正常动脉的三分之一，与原始SIS移植物相似。重塑后的移植物厚度是植入的SIS的10倍以上。对重塑组织的免疫组织化学分析表明，SIS材料随时间推移会降解和吸收。重塑过程将一种在物理和力学上与正常主动脉有很大不同的材料转变为一种具有在该哺乳动物动脉系统中发挥功能所需物理和力学性能的血管管道。
