器官移植不断变化的免疫学
The changing immunology of organ transplantation.
作者信息
Starzl T E, Demetris A J, Murase N, Trucco M, Thomson A W, Rao A S
机构信息
University of Pittsburgh, USA.
出版信息
Hosp Pract (1995). 1995 Oct 15;30(10):31-4, 37-42. doi: 10.1080/21548331.1995.11443268.
Abstract
The engrafted organ becomes a chimera as the recipient's leukocytes station themselves in the transplant. Remarkably, the recipient becomes chimeric as well, in a reverse migration involving immune cells from the graft. Interactions between donor and recipient cells are tolerogenic--a process with implications for the goal of graft acceptance with minimal immunosuppression.
摘要
植入的器官会变成嵌合体，因为受者的白细胞会在移植器官中驻留。值得注意的是，受者也会变成嵌合体，这是一个涉及来自移植物的免疫细胞的逆向迁移过程。供体细胞与受体细胞之间的相互作用具有耐受性——这一过程对于以最小免疫抑制实现移植物接受的目标具有重要意义。
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本文引用的文献
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