用二甲基硫脲进行长期治疗可抑制NZB×NZWF1小鼠自身免疫性疾病的发展。
Long-term treatment with dimethylthiourea inhibits the development of autoimmune disease in NZB x NZWF1 mice.
作者信息
Hayashi T, Kameyama Y, Shirachi T
机构信息
Laboratory of Veterinary Pathology, Faculty of Agriculture, Yamaguchi University, Japan.
出版信息
J Comp Pathol. 1995 May;112(4):423-8. doi: 10.1016/s0021-9975(05)80023-4.
Long-term treatment with dimethylthiourea (DMTU), a scavenger of hydroxyl radical (.OH) and hypochlorous acid (HOCl), suppressed the age-related development of autoimmune disease in NZB x NZWF1 mice. Treatment reduced autoantibody production, retarded increase in blood urea nitrogen, and prolonged life. The results suggest that .OH and HOCl may, at least in part, enhance the development of autoimmune diseases in NZB x NZWF1 mice.
用二甲基硫脲（DMTU，一种羟自由基（·OH）和次氯酸（HOCl）清除剂）进行长期治疗，可抑制NZB×NZWF1小鼠自身免疫性疾病的年龄相关性发展。治疗减少了自身抗体的产生，延缓了血尿素氮的升高，并延长了寿命。结果表明，·OH和HOCl可能至少在一定程度上促进了NZB×NZWF1小鼠自身免疫性疾病的发展。
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