Bulay O, Urman H, Patil K, Clayson D B, Shubik P
Int J Cancer. 1979 Jan 15;23(1):97-104. doi: 10.1002/ijc.2910230117.
Hycanthone was administered to Schistosoma mansoni-infected and non-infected Syrian golden hamsters and Swiss mice by intraperitoneal and intramuscular injection of amounts up to the maximum tolerated dose. No tumors attributable to treatment were observed in hamsters. In infected mice, the overall incidence of hepatomas and hepatocellular carcinomas increased from 3.4% in untreated mice to 10.6% in those treated with hycanthone. Non-infected control mice developed 0.8% of these tumors compared to 10.2% in mice treated with hycanthone. Despite the use of high dose levels of hycanthone, statistical significance was attained only with non-infected female mice injected intraperitoneally and intramuscularly with hycanthone and then only at confidence levels of 92 and 95% respectively.
对感染曼氏血吸虫和未感染的叙利亚金仓鼠及瑞士小鼠腹腔内和肌肉内注射海蒽酮，剂量高达最大耐受剂量。在仓鼠中未观察到与治疗相关的肿瘤。在感染的小鼠中，肝癌和肝细胞癌的总体发生率从未治疗小鼠的3.4%增加到用海蒽酮治疗小鼠的10.6%。未感染的对照小鼠发生这些肿瘤的比例为0.8%，而用海蒽酮治疗的小鼠为10.2%。尽管使用了高剂量的海蒽酮，但仅在腹腔内和肌肉内注射海蒽酮的未感染雌性小鼠中达到统计学显著性，且分别仅在92%和95%的置信水平上。
