Thoft R A, Friend J, Murphy H S
Invest Ophthalmol Vis Sci. 1979 Jan;18(1):85-92.
A new model for rabbit corneal vascularization, created by making a penetrating wound in corneas with epithelium of conjunctival origin, is described. Obligate resurfacing of the cornea from conjunctival epithelium usually leads to a small, but consistent peripheral superficial corneal vascularization. Subsequent penetrating wounds elicit, in 75% of cases, a marked vascular ingrowth. Normal eyes and eyes resurfaced by peripheral corneal epithelial cells do not vascularize after such wounds. The vessels are located in the anterior corneal stroma, and the regenerated epithelium has a conjunctival appearance. Although increased hydration plays a role in this vascularization, the extent of vascularization was much greater in the presence of regenerated epithelium of conjunctival origin than in the presence of regenerated epithelium of corneal origin.
本文描述了一种通过在具有结膜来源上皮的角膜上制造穿透性伤口而建立的兔角膜血管化新模型。结膜上皮对角膜进行的强制性再上皮化通常会导致小范围但持续存在的周边浅层角膜血管化。随后的穿透性伤口在75%的病例中会引发明显的血管向内生长。正常眼睛以及由周边角膜上皮细胞进行再上皮化的眼睛在遭受此类伤口后不会发生血管化。血管位于角膜前基质层，再生上皮具有结膜外观。尽管水分增加在这种血管化过程中起一定作用，但与角膜来源的再生上皮相比，结膜来源的再生上皮存在时血管化程度要大得多。
