Tepavcević D, Giljević Z, Aganović I, Korsić M, Halimi S, Suchanek E, Jelić T, Kozić B, Plavsić V
Department of Internal Medicine, Zagreb University School of Medicine, Croatia.
J Endocrinol Invest. 1995 Jun;18(6):427-30. doi: 10.1007/BF03349740.
The role of serotonin in the insulin hypoglycemia (IH) stimulated secretion of prolactin (PRL), growth hormone (GH), adrenocorticotropin (ACTH) and cortisol (F) was studied in a group of 12 normal subjects during the control period after placebo and a consecutive six-day treatment with 20 mg ritanserin (RIT) per day. RIT failed to affect the baseline levels of all the four hormones as well as the PRL response to IH (p > 0.5). The serum GH response to IH was moderately diminished after RIT, the reduction of integrated trapezoidal area under hormone curves (nAUC) being 50.7% +/- 6.9% (p < 0.005). Furthermore, RIT was found to slightly decrease the plasma ACTH response to IH, the reduction of nAUC being 36.3% +/- 2.6% (p < 0.005). Decrease in the corresponding plasma F response to IH was accompanied by 29.1% +/- 2.4% reduction of nAUC (p < 0.005). According to our results, serotonin-S2 receptors appeared to be moderately involved in IH-induced release of GH, but slightly in that of ACTH, leaving unaffected that of PRL.
在一组12名正常受试者中，研究了5-羟色胺在胰岛素低血糖（IH）刺激下催乳素（PRL）、生长激素（GH）、促肾上腺皮质激素（ACTH）和皮质醇（F）分泌中的作用。在服用安慰剂后的对照期以及连续6天每天服用20 mg利坦色林（RIT）的治疗期进行研究。RIT未能影响所有这四种激素的基线水平以及PRL对IH的反应（p>0.5）。RIT治疗后，血清GH对IH的反应中度减弱，激素曲线下积分梯形面积（nAUC）减少50.7%±6.9%（p<0.005）。此外，发现RIT略微降低血浆ACTH对IH的反应，nAUC减少36.3%±2.6%（p<0.005）。血浆F对IH的相应反应降低，nAUC减少29.1%±2.4%（p<0.005）。根据我们的结果，5-羟色胺-S2受体似乎中度参与IH诱导的GH释放，但略微参与ACTH的释放，而对PRL的释放没有影响。
