Komuro Y, Ishii K, Miyake Y, Tanabe S, Oida M, Saigenji K
Department of Internal Medicine, Kitasato University School of Medicine, Kanagawa, Japan.
J Clin Gastroenterol. 1995;20 Suppl 2:S47-51. doi: 10.1097/00004836-199506002-00013.
The effect of lansoprazole, a new benzimidazole proton pump inhibitor, on the relationship between ulcer healing and changes in mucin content was studied in gastric ulcer patients. Twenty-one outpatients with active gastric ulcers received lansoprazole 30 mg once daily given in the morning for 8 weeks. The gastric mucin content was examined by HPLC analysis of hexosamines in gastric biopsy specimens obtained from the lesser curvature of the pylorus and the greater curvature of the upper body. The ulcer healing rate for lansoprazole was 85.7% at 8 weeks. The mucin content of both mucosal regions significantly decreased to approximately 70% (pylorus 70.9%; upper body 74.7%) of the value before drug treatment. The results of this study demonstrate that 30 mg lansoprazole once daily is remarkably effective in healing gastric ulcers because of its potent acid suppression. It appears that acid inhibition is the primary factor in initial treatment. However, maintaining an altered gastric mucosal defense mechanism may have implications for the long-term treatment of gastric ulcers.
在胃溃疡患者中研究了新型苯并咪唑质子泵抑制剂兰索拉唑对溃疡愈合与黏蛋白含量变化之间关系的影响。21例活动性胃溃疡门诊患者接受兰索拉唑30毫克，每天早晨服用一次，共8周。通过对取自幽门小弯和胃体大弯的胃活检标本中的己糖胺进行HPLC分析来检测胃黏蛋白含量。兰索拉唑治疗8周时溃疡愈合率为85.7%。两个黏膜区域的黏蛋白含量均显著下降至药物治疗前值的约70%（幽门70.9%；胃体74.7%）。本研究结果表明，由于兰索拉唑强效抑制胃酸，每天一次30毫克对愈合胃溃疡非常有效。似乎抑制胃酸是初始治疗的主要因素。然而，维持改变的胃黏膜防御机制可能对胃溃疡的长期治疗有影响。
