Jones A W, Andersson L
Department of Alcohol Toxicology, University Hospital, Linköping, Sweden.
J Forensic Sci. 1995 Jul;40(4):686-7.
We report the identification of acetone (0.45 mg/mL) and isopropanol (0.17 mg/mL) but without the presence of ethanol in a blood sample from a man suspected of driving under the influence of alcohol. A preliminary breath screening test with an electrochemical instrument (Alcolmeter S-L2) was positive and an evidential breath-test with a dual wavelength infrared analyzer (Intoxilyzer 5000), recognized the presence of an interferant in the subject's breath. The man admitted drinking moderate amounts of alcohol (vodka) the previous evening and was being treated by his doctor for hyperglycemia by special dietary control. This case scenario provides a good example of severe metabolic ketoacidosis in an ostensibly healthy man driving on the highway. Biotransformation of the abnormally high concentration of blood-acetone to isopropanol occurs through the alcohol dehydrogenase pathway.
我们报告了在一名涉嫌酒后驾车男子的血液样本中鉴定出丙酮（0.45毫克/毫升）和异丙醇（0.17毫克/毫升），但未检测到乙醇。使用电化学仪器（Alcolmeter S-L2）进行的初步呼气筛查测试呈阳性，而使用双波长红外分析仪（Intoxilyzer 5000）进行的证据呼气测试识别出该受试者呼气中存在干扰物。该男子承认前一晚饮用了适量酒精（伏特加），并且因其医生通过特殊饮食控制来治疗他的高血糖症。此案例为一名表面健康的男子在高速公路上驾车时发生严重代谢性酮症酸中毒提供了一个很好的例子。血液中异常高浓度的丙酮通过乙醇脱氢酶途径生物转化为异丙醇。
