Lewis G D, Laufman A K, McAnalley B H, Garriott J C
J Forensic Sci. 1984 Apr;29(2):541-9.
Isopropyl alcohol and acetone have been detected in autopsy blood samples of individuals not previously exposed to these compounds. Since some of these individuals had a history of diabetes mellitus, it has been suggested that in these cases, reduction of acetone to isopropyl alcohol might be a metabolic pathway for its production. This hypothesis was investigated in a study of normal and diabetic rats. Acute administration of acetone resulted in measureable levels of isopropyl alcohol in blood. Metabolism of acetone to isopropyl alcohol was different in normal and diabetic animals. Blood levels of isopropanol reached a maximum at the second highest dose in normal rats, but there was a two-phase response in diabetic rats. In a second series of experiments, acetone was administered on alternate days for a week. In spite of this chronic administration (and persistence of high blood acetone), there was no enhancement of acetone metabolism to isopropyl alcohol. These experiments indicate that high levels of blood acetone could result in transformation to isopropyl alcohol.
在之前未接触过异丙醇和丙酮的个体尸检血样中检测到了这两种物质。由于其中一些个体有糖尿病史，因此有人提出，在这些病例中，丙酮还原为异丙醇可能是其产生的一种代谢途径。在一项针对正常大鼠和糖尿病大鼠的研究中对这一假设进行了调查。急性给予丙酮后，血液中可检测到异丙醇水平。正常动物和糖尿病动物中丙酮向异丙醇的代谢情况不同。在正常大鼠中，异丙醇的血液水平在第二高剂量时达到最高，但糖尿病大鼠呈现双相反应。在第二系列实验中，连续一周隔天给予丙酮。尽管进行了这种长期给药（且血液中丙酮持续存在），丙酮向异丙醇的代谢并未增强。这些实验表明，血液中高浓度的丙酮可能会转化为异丙醇。
