Casale J F, Moore J M, Cooper D A
Special Testing and Research Laboratory, U.S. DEA, McLean, VA, USA.
J Forensic Sci. 1995 Sep;40(5):816-22.
Several novel chlorinated tropanes were produced when cocaine was treated with aqueous sodium hypochlorite. Two of these, 2'- and 3'-chlorobenzoyloxy-2-carbomethoxypseudotropine (that is, ortho- and meta-chlorococaine), were characterized by synthesis and gas chromatography/mass spectrometry. Four other new chlorinated tropanes (endo-6- and 7-chlorococaine, exo-6- or 7-chlorococaine and N-chlorobenzoylnorecgonine methyl ester) were also tentatively identified via their gas chromatography retention data and mass spectra. The results are of potential use in cocaine signature and comparative analysis.
用次氯酸钠水溶液处理可卡因时会生成几种新型氯化托烷。其中两种，即2'-和3'-氯苯甲酰氧基-2-甲氧羰基假托品（即邻氯可卡因和间氯可卡因），通过合成和气相色谱/质谱法进行了表征。另外四种新的氯化托烷（内型-6-和7-氯可卡因、外型-6-或7-氯可卡因以及N-氯苯甲酰去甲芽子碱甲酯）也通过其气相色谱保留数据和质谱进行了初步鉴定。这些结果在可卡因特征和比较分析中具有潜在用途。
