意外的氟卡尼与酒精中毒。

Unsuspected self-poisoning with flecainide and alcohol.

作者信息

Sadler D W, Quigley C

机构信息

Department of Forensic Medicine, Dundee Royal Infirmary, Scotland.

出版信息

J Forensic Sci. 1995 Sep;40(5):903-5.

PMID:7595337

Abstract

The death of a 23-year-old man by suicidal flecainide and alcohol poisoning is reported. Flecainide was identified by ultraviolet (UV) spectrophotometry and gas chromatography-mass spectrometry (GC-MS). Flecainide levels, quantitated by high performance liquid chromatography (HPLC) with UV detection were: femoral blood 7.3 mg/L, urine 117 mg/L, stomach contents 19 mg and liver 302 mg/kg. Ethanol levels in femoral blood, urine and vitreous humor were 107, 136 and 113 mg%, respectively. The importance of carefully considering all the available pathological and toxicological data, together with the past medical history and circumstances surrounding the death in poisoning cases is emphasized.

摘要

据报道，一名23岁男子死于自杀性氟卡尼和酒精中毒。通过紫外（UV）分光光度法和气相色谱-质谱联用（GC-MS）鉴定出氟卡尼。采用带紫外检测的高效液相色谱法（HPLC）定量的氟卡尼水平为：股血7.3 mg/L、尿液117 mg/L、胃内容物19 mg以及肝脏302 mg/kg。股血、尿液和玻璃体液中的乙醇水平分别为107、136和113 mg%。强调了在中毒案件中仔细考虑所有可用的病理和毒理学数据以及过去病史和死亡周围情况的重要性。